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Mcl-1 Protein and Viral Infections: A Narrative Review.
Zbigniew Wyżewski1, Justyna Stępkowska2, Aleksandra Maria Kobylińska3
1Institute of Biological Sciences, Cardinal Stefan Wyszyński University in Warsaw, Dewajtis 5, 01-815 Warsaw, Poland.
International Journal of Molecular Sciences
|January 23, 2024
Summary
Myeloid cell leukemia 1 (MCL-1), a key apoptosis regulator, is manipulated by viruses to control cell death and aid replication. Targeting MCL-1 offers a novel therapeutic strategy for viral diseases and cancers.
Area of Science:
- Molecular Biology
- Virology
- Cell Biology
Background:
- MCL-1 (myeloid cell leukemia 1) is a crucial prosurvival protein in the Bcl-2 family, inhibiting apoptosis.
- Viral infections exploit host cell apoptosis pathways to regulate pathogen replication and dissemination.
- Deregulation of MCL-1 levels by viruses is implicated in various virus-driven diseases.
Purpose of the Study:
- To elucidate the role of MCL-1 in viral infections.
- To identify potential antiviral agents targeting MCL-1.
- To explore MCL-1-targeted therapies for viral diseases and cancers.
Main Methods:
- Literature review on MCL-1's function in viral infections.
- Analysis of studies detailing virus-induced MCL-1 modulation.
- Compilation of antiviral agents targeting MCL-1.
Main Results:
- Viruses modulate intracellular MCL-1 levels to control infected cell apoptosis, influencing replication and spread.
- Specific viral infections are linked to MCL-1 level dysregulation.
- A list of promising MCL-1-targeting antiviral agents was identified.
Conclusions:
- Targeting anti-apoptotic MCL-1 presents a novel therapeutic avenue for viral infections, cancers, and other diseases.
- Understanding virus-MCL-1 interactions enhances knowledge of cell death regulation.
- Further investigation into these mechanisms could lead to improved therapeutic strategies.
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