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Articles linked to this work by shared authors, journal, and citation graph.

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Regenerative Peripheral Nerve Interface (RPNI) and vascularized Denervated Muscle Targets (VDMT): a preclinical rabbit model as a translational feasibility and methodological platform.

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Related Experiment Video

Updated: Jul 5, 2025

Fabrication of the Composite Regenerative Peripheral Nerve Interface C-RPNI in the Adult Rat
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Regenerative Peripheral Nerve Interfaces (RPNIs) in Animal Models and Their Applications: A Systematic Review.

Jorge González-Prieto1,2, Lara Cristóbal1,2, Mario Arenillas3

  • 1Peripheral Nerve Unit, Department of Plastic Surgery, University Hospital of Getafe, 28905 Madrid, Spain.

International Journal of Molecular Sciences
|January 23, 2024
PubMed
Summary
This summary is machine-generated.

Regenerative Peripheral Nerve Interfaces (RPNIs) amplify nerve signals using muscle grafts. This review analyzes animal models, finding murine and macaque models effective for RPNI research.

Keywords:
Burrito-RPNIInlay-RPNIRegenerative Peripheral Nerve Interfaces (RPNIs)animal modelsmyoelectric prosthesesneuroma preventionsystematic review

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Regenerative Medicine

Background:

  • Regenerative Peripheral Nerve Interfaces (RPNIs) utilize neurotized muscle grafts to amplify peripheral nerve signals.
  • Understanding the animal models employed in RPNI research is crucial for advancing the field.

Approach:

  • A systematic literature review adhering to PRISMA guidelines was conducted.
  • Searched MEDLINE/PubMed and Embase databases from January 1970 to September 2023 for RPNI studies in animal models.
  • Analyzed 35 studies using animal models, focusing on common peroneal nerve and extensor digitorum longus muscle RPNIs.

Key Points:

  • The majority of studies (91%) utilized murine models, with a smaller portion (9%) using macaque models.
  • Histological analysis confirmed robust neoangiogenesis and axonal regeneration within RPNIs.
  • RPNIs demonstrated stable, long-term capability in discerning, recording, and amplifying action potentials.

Conclusions:

  • RPNI techniques have been successfully replicated across various animal models.
  • This review summarizes histological, neurophysiological, and functional data to inform future RPNI research.
  • Further investigation into diverse animal models can optimize RPNI development for clinical translation.