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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Fat Matters: Exploring Cancer Risk through the Lens of Computed Tomography and Visceral Adiposity
Federico Greco1,2, Claudia Lucia Piccolo2,3, Valerio D'Andrea2,3
1Department of Radiology, Cittadella della Salute Azienda Sanitaria Locale di Lecce, Piazza Filippo Bottazzi 2, 73100 Lecce, Italy.
Journal of Clinical Medicine
|January 23, 2024
Summary
Obesity increases cancer risk, but visceral adipose tissue (VAT) quantity, precisely measured by CT scans, is a key factor in tumor development. Understanding VAT
Area of Science:
- Oncology
- Radiology
- Metabolic Disease
Background:
- Obesity is a known cancer risk factor.
- Body mass index lacks precision in quantifying abdominal fat depots.
- Visceral adipose tissue (VAT) has high metabolic activity and influences cancer development.
Purpose of the Study:
- To determine the role of computed tomography (CT) in assessing VAT quantity and distribution for obesity-related cancer.
- To highlight the importance of VAT quantification in precision oncology.
Main Methods:
- Utilizing CT scans, typically performed for cancer staging.
- Precisely quantifying visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT).
Main Results:
- Previous studies indicate VAT is a risk factor for clear cell renal cell carcinoma, non-clear cell renal cell carcinoma, prostate cancer, and hepatocarcinoma recurrence.
- CT enables accurate quantification of abdominal fat compartments.
Conclusions:
- Accurate VAT quantification using CT is crucial for understanding its role in obesity-related cancer.
- Further research should explore VAT's relationship with tumor genomics in various cancers.
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