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Related Concept Videos

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Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Updated: Jun 23, 2026

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci
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Trans-Cinnamaldehyde-Fighting Streptococcus mutans Using Nature.

Zilefac Brian Ngokwe1,2, Amit Wolfoviz-Zilberman1, Esi Sharon1

  • 1Department of Prosthodontics, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Pharmaceutics
|January 23, 2024
PubMed
Summary

Trans-cinnamaldehyde (TC) effectively combats Streptococcus mutans, the primary cause of tooth decay. This phytochemical shows potent antibacterial and antibiofilm effects, offering a promising natural strategy against dental caries.

Keywords:
S. mutansantibacterialantibiofilmpreformed biofilmstrans-cinnamaldehyde

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Area of Science:

  • Microbiology
  • Biochemistry
  • Dental Research

Background:

  • Streptococcus mutans is the principal cariogenic bacterium responsible for tooth demineralization and caries formation.
  • Its acidogenic and aciduric properties contribute significantly to its virulence.
  • Phytochemicals, such as trans-cinnamaldehyde (TC) from cinnamon, are known for their broad-spectrum antibacterial activities.

Purpose of the Study:

  • To investigate the antibacterial and antibiofilm efficacy of trans-cinnamaldehyde (TC) against Streptococcus mutans.
  • To determine the minimum bactericidal concentration (MBC) and sub-MBC effects of TC on S. mutans.

Main Methods:

  • In vitro assessment of TC's antibacterial activity against planktonic S. mutans.
  • Determination of TC's minimum bactericidal concentration (MBC) using a microplate spectrophotometer.
  • Evaluation of antibiofilm effects using sub-MBC doses of TC on hydroxyapatite discs, analyzed by spinning-disk confocal microscopy (SDCM) and high-resolution scanning electron microscopy (HR-SEM).

Main Results:

  • The minimum bactericidal concentration (MBC) of TC against planktonic S. mutans was determined to be 2500 μg/mL.
  • Dimethyl sulfoxide (DMSO) solvent controls exhibited no antibacterial effect.
  • Sub-MBC doses of TC, specifically ≥625 μg/mL, demonstrated significant antibiofilm activity against S. mutans.

Conclusions:

  • Trans-cinnamaldehyde (TC) exhibits potent antibacterial and antibiofilm properties against Streptococcus mutans.
  • A concentration of 625 μg/mL of TC was identified as the most effective sub-MBC dose for these activities.
  • TC presents a promising natural compound for developing novel strategies against cariogenic bacteria and dental caries.