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Updated: Jul 5, 2025

Preparation of Fungal and Plant Materials for Structural Elucidation Using Dynamic Nuclear Polarization Solid-State NMR
Published on: February 12, 2019
Overcoming NMR line broadening of nitrogen containing compounds: A simple solution
Junhe Ma1, Qingmei Ye1, Rebecca A Green1
1Chemical Process Development, Bristol Myers Squibb Company, New Brunswick, New Jersey, USA.
Abstract:
This study presents a straightforward solution to the challenge of elucidating the structures of nitrogen containing compounds undergoing isomerization. When spectral line broadening occurs related to isomerization, be it prototropic tautomerism or bond rotations, this poses a significant obstacle to structural elucidation. By adding acids, we demonstrate a simple approach to overcome this issue and effectively sharpen NMR signals for acid stable prototropic tautomers as well as the conformational isomers containing a morpholine or piperazine ring.
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