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Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
Published on: April 21, 2023
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Single-molecule detection assisted by the target-triggered signal amplification strategy for ultrasensitive
Chengfang Jiang1, Qi Wang1, Jing Geng2
1College of Chemistry and Chemical Engineering, Linyi University, P. R. China.
Chemical Communications (Cambridge, England)
|January 23, 2024
Abstract:
We developed a multiplex single-molecule quantitative assay of intracellular telomerase that used target-triggered signal amplification to enhance sensitivity, substrate reaction to increase signal stability, and quantum dots to enhance signal-to-noise ratio, obtaining an LOD of 5 × 10-14 IU for intracellular telomerase and LOD of 3 cells for multiple cancer cells.
