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Prevalence and factors associated with medication adherence in children with central precocious puberty: a

Chunsong Yang1,2,3,4, Xia Song1,2,3,4,5, Jin Wu6

  • 1Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.

Frontiers in Pharmacology
|January 23, 2024
PubMed

Insights

Medication adherence in children with central precocious puberty (CPP) is generally good, but caregiver factors like understanding medication harm and cost influence adherence. Enhancing caregiver education is key to improving treatment outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Pharmacology
  • Public Health

Background:

  • Central precocious puberty (CPP) requires long-term medication adherence for effective treatment.
  • Factors influencing medication adherence in pediatric CPP patients are not fully understood.
  • Optimizing adherence is crucial for achieving desired therapeutic outcomes and preventing complications.

Purpose of the Study:

  • To determine the prevalence of medication adherence in children with CPP.
  • To identify factors associated with medication adherence in this pediatric population.
  • To inform clinical strategies for improving adherence in CPP management.

Main Methods:

  • A cross-sectional study was conducted with 125 children with CPP and their caregivers.
  • Data collected via questionnaires included patient/caregiver characteristics, medication details, and adherence using the MMAS-8 scale.
  • Univariate and multivariate analyses were performed to identify influencing factors.

Main Results:

  • The overall medication adherence rate in children with CPP was 76.0%.
  • Poor adherence was associated with caregiver factors such as education level, financial burden, and medication cognition.
  • Independent risk factors for poor adherence included adverse effects, lack of understanding non-compliance harm, and perceived high medication cost.

Conclusions:

  • Medication adherence in pediatric CPP is relatively high, with caregiver-related factors playing a significant role in non-adherence.
  • Targeted health education for caregivers is recommended to improve understanding of CPP and its treatment.
  • Enhancing caregiver cognition can lead to better medication adherence and improved therapeutic efficacy.

Keywords:
central precocious pubertychildrencrosssectional surveyinfluencing factorsmedication adherence

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