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Related Experiment Video

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Rat Model of Adhesive Capsulitis of the Shoulder
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Anxiety disorders and adhesive capsulitis: a bidirectional Mendelian randomization study.

Yi Ouyang1, Miaomiao Dai2

  • 1Department of Joint Surgery, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, China.

Frontiers in Immunology
|January 23, 2024
PubMed
Summary

Anxiety disorders causally increase the risk of adhesive capsulitis (AC). However, adhesive capsulitis (AC) does not appear to causally increase the risk of anxiety disorders, according to this genetic study.

Keywords:
Mendelian randomizationadhesive capsulitisanxiety disorderscausalityfrozen shoulder

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Area of Science:

  • Medical research
  • Genetics
  • Epidemiology

Background:

  • Anxiety disorders and adhesive capsulitis (AC) share an observed association.
  • The causal relationship between anxiety disorders and AC remains unclear.
  • Previous studies have not fully elucidated the bidirectional causality.

Purpose of the Study:

  • To investigate the causal link between anxiety disorders and AC.
  • To examine the potential reverse causality from AC to anxiety disorders.
  • Utilize a bidirectional, two-sample Mendelian randomization (MR) approach.

Main Methods:

  • Obtained genomewide association study datasets for anxiety disorders and AC.
  • Selected and screened single nucleotide polymorphisms as instrumental variables.
  • Employed inverse variance weighting (IVW) and sensitivity analyses for causality assessment.

Main Results:

  • Found significant evidence for a causal effect of anxiety disorders on increased susceptibility to AC (OR=1.267, P=9.362 × 10^-6).
  • Reverse Mendelian randomization analysis did not support a causal link from AC to anxiety disorders.
  • Sensitivity analyses confirmed the robustness of the findings.

Conclusions:

  • Anxiety disorders are causally associated with an increased risk of developing adhesive capsulitis (AC).
  • No significant evidence supports a reciprocal genetic causal relationship from AC to anxiety disorders.
  • The findings clarify the unidirectional causal link between these conditions.