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Updated: Jul 5, 2025

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Exploring the evolving function of soluble intercellular adhesion molecule-1 in junction dynamics during

Xiang Xiao1,2, Yating Han1,3, Qin Li4

  • 1Center for Reproductive Health, School of Pharmaceutical Sciences, Hangzhou Medical College (Zhejiang Academy of Medical Sciences), Hangzhou, China.

Frontiers in Endocrinology
|January 23, 2024
PubMed
Summary

Soluble intercellular adhesion molecule-1 (sICAM-1) weakens the blood-testis barrier (BTB) and impairs sperm production. sICAM-1 may regulate BTB permeability by influencing SRC signaling, offering potential therapeutic targets for male infertility.

Keywords:
Sertoli cellsblood-testis barrier (BTB)cytoskeletonmale fertilitysoluble intercellular adhesion molecule-1 (sICAM-1)spermatogenesistestis

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