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Updated: Jul 5, 2025

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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Neuronal microstructural changes in the human brain are associated with neurocognitive aging.

Kavita Singh1, Stephanie Barsoum1, Kurt G Schilling2

  • 1Multiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, NIH, Baltimore, MD, USA.

Biorxiv : the Preprint Server for Biology
|January 23, 2024
PubMed
Summary

Diffusion MRI reveals early microstructural brain changes associated with aging and cognitive decline, preceding visible atrophy. These subtle alterations, not macroscopic changes, correlate with neurobehavioral performance in aging adults.

Keywords:
MRIagingdiffusiongray mattermicrostructureneurocognitive aging

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