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Updated: Jul 5, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

Ying Qin1,2, Dekang Li1,2, Chunting Qi1

  • 1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.

Acta Pharmaceutica Sinica. B
|January 23, 2024
PubMed

Keywords:
Anti-inflammationLead optimizationNecroptosisPreclinical drug discoveryRIPK1Rational designStructure‒activity relationshipType-II kinase inhibitors

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