[Characteristics of glycogen metabolic regulation in rats with experimental autoimmune cardiomyopathy]

Alterations in glycogen metabolism and in its regulation were found in heart muscle and liver tissue, but not in sceletal muscle, of rats with experimental autoimmune cardiomyopathy. In development of the pathological process content of glycogen was unaltered in heart muscle as compared with the normal state; at the same time, activities of glycogen synthetase, phosphorylase and acid alpha-glucosidase were increased. After administration of adrenaline, noradrenaline and serotonin into animals with the cardiomyopathy, the phosphorylase from heart muscle was not activated, contrary to the respone of the enzyme under normal conditions. Content of glycogen was drastically increased in liver tissue of rats with experimental cardiomyopathy, as compared with the normal state. Aministration of biogenic amines into the animals led to a decrease in concentration of glycogen in liver tissue and to increase in activity of acid alpha-glucosidase, but did not affect the activities of phosphorylase A and glycogen synthetase. A possibility is considered for a decrease of the abnormally high content of glycogen in liver tissue of the impaired rats using treatment with biogenic amines.