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Related Experiment Video

Updated: Jul 5, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Relationship between autism and brain cortex surface area: genetic correlation and a two-sample Mendelian

Xianjing Li¹, Miaomiao Jiang¹, Liyang Zhao¹

¹NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital, Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing, China.

|January 23, 2024

Summary

Genetic analysis reveals a link between autism spectrum disorder (ASD) and cortical surface area (SA) differences in specific brain regions. This study provides evidence for the genetic underpinnings of these variations in individuals with ASD.

Keywords:

Autism spectrum disorder Cortical surface area Genetic correlation Mendelian randomization analysis

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Area of Science:

Neurogenetics
Developmental Neuroscience
Psychiatric Genomics

Background:

Cortical surface area (SA) alterations are observed in autism spectrum disorder (ASD), but the genetic basis remains unclear.
This study investigates the genetic correlation and causal relationship between ASD and cortical SA.

Conclusions:

The findings provide genetic evidence supporting the association between ASD and specific cortical SA differences.
This research contributes to a better understanding of the genetic relationship between autism spectrum disorder and cortical surface area variations.