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The relationship between kidney disease and mitochondria: a bibliometric study
Jueyi Mao1, Cuifang Li1, Feifeng Wu1
1Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, China.
Renal Failure
|January 24, 2024
Summary
Mitochondria are crucial for kidney function. Research shows a shift towards understanding mitochondrial mechanisms in kidney disease, particularly diabetic nephropathy and reactive oxygen species (ROS) production.
Area of Science:
- Nephrology
- Mitochondrial Biology
- Biomedical Research
Background:
- Kidneys are highly mitochondria-dependent due to their reabsorptive functions.
- The link between mitochondria and kidney disease is a significant research area with extensive publications.
- Bibliometrics offers a method to analyze research trends and identify key areas in this field.
Purpose of the Study:
- To analyze the development trends and research hotspots concerning the association between mitochondria and kidney disease.
- To provide a comprehensive overview of the current literature using bibliometric analysis.
Main Methods:
- Utilized three bibliometric mapping tools: Biblimetrix R Package, VOS Viewer, and CiteSpace.
- Analyzed a dataset of 2672 research articles.
- Examined keyword co-occurrence and citation networks to identify research clusters and trends.
Main Results:
- Identified three main research clusters: experimental methods, research mechanisms, and disease phenotypes.
- Observed a research shift from disease-level studies to mechanism-based investigations.
- Highlighted diabetic nephropathy as the most studied kidney disease and mitochondrial reactive oxygen species (ROS) production as a key pathogenic mechanism.
Conclusions:
- Bibliometric analysis offers a thorough understanding of research progress on mitochondria in kidney disease.
- This study enriches existing review literature by mapping the field's landscape.
- Identified key trends and hotspots in mitochondria-kidney disease research.
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