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Updated: Jul 5, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-light-induced radical cascade cyclization: a catalyst-free synthetic approach to trifluoromethylated
Chuan Yang1,2, Wei Shi1,2, Jian Tian2
1College of Chemical and Material Engineering, Quzhou University, Quzhou 324000, China.
Abstract:
A visible-light-promoted research protocol for constructing dihydropyrido[1,2-a]indolone skeletons is herein described proceeding through a cascade cyclization mediated by trifluoromethyl radicals. This method allows the efficient synthesis of various indole derivatives without the need of photocatalysts or transition-metal catalysts. Mechanism experiments indicate that the process involves a radical chain process initiated by the homolysis of Umemoto's reagent. This straightforward method enables a rapid access to heterocycles containing a trifluoromethyl group.
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