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Related Experiment Video

Updated: Jul 5, 2025

Intravascular Delivery of Biologics to the Rat Kidney

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

Extended-release buprenorphine in pregnancy.

Alexander Hubbell¹, Ese Aghenta², Cresta Jones³

¹M Health Fairview Addiction Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

The American Journal on Addictions

|January 24, 2024

Summary

Monthly extended-release buprenorphine (XR-BUP) use during pregnancy resulted in positive patient experiences and healthy infants in a case report. Further research is needed to fully evaluate XR-BUP safety and efficacy in pregnant populations.

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Area of Science:

Obstetrics and Gynecology
Addiction Medicine
Pharmacology

Background:

The safety and efficacy of monthly extended-release buprenorphine (XR-BUP) during pregnancy remain under-evaluated.
Limited data hinders informed decision-making for pregnant individuals considering XR-BUP treatment.

Observation:

This case report details the experiences of two pregnant individuals undergoing XR-BUP treatment.
Both individuals received XR-BUP throughout their pregnancies.

Findings:

Both patients reported positive experiences with XR-BUP therapy.
Both patients delivered healthy infants, suggesting favorable outcomes.

Implications:

This report contributes valuable, previously unreported data on XR-BUP use in pregnancy.
Findings support further investigation into XR-BUP for pregnant patients with opioid use disorder.
This evidence can aid clinicians and patients in risk-benefit discussions regarding XR-BUP during gestation.