Common and distinct patterns underlying different linguistic tasks: multivariate disconnectome symptom mapping in...

Area of Science:

• Cognitive Neuroscience
• Neurolinguistics
• Neuroimaging

Background:

• Neural mechanisms of speech comprehension and production are extensively studied.
• Understanding similarities and differences in neural patterns across linguistic tasks remains a challenge.

Purpose of the Study:

• To compare neural patterns underlying speech comprehension and production.
• To investigate shared and distinct brain regions involved in these tasks.

Main Methods:

• Applied multivariate regression with lesion/disconnection symptom mapping.
• Analyzed data from 216 stroke patients with left hemisphere damage.

Main Results:

• Lesion patterns predicted speech comprehension and production task performance.
• Identified shared regions (left temporal pole) and unique regions for each task.
• Speech comprehension deficits linked to temporal lobe lesions; production deficits linked to parietal and frontal lobe lesions.

Conclusions:

• Results support the dual stream model, highlighting ventral and dorsal pathways for speech comprehension and production.
• Demonstrated the utility of multivariate disconnectome-based symptom mapping in cognitive neuroscience.