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Updated: Jul 5, 2025

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

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Published on: July 18, 2014

How Precisely Can Individual Molecules Be Analyzed? A Case Study on Locally Quantifying Forces and Energies Using

Xinzhe Wang¹, Percy Zahl², Hailiang Wang³

¹Department of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut 06511, United States.

|January 24, 2024

Summary

This summary is machine-generated.

Scanning probe microscopy precisely maps molecule interactions. This study quantifies tip-molecule forces and energies for cobalt phthalocyanine (CoPc) on silver, revealing physisorption details.

Keywords:

cobalt phthalocyanines molecular catalysts noncontact atomic force microscopy scanning tunneling force microscopy site-specific quantification of forces surface catalysis three-dimensional atomic force microscopy

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Area of Science:

Surface Science
Chemical Physics
Materials Science

Background:

Scanning probe microscopy (SPM) advances enable picometer-accurate, 3D measurements of tip-sample interactions.
Understanding local probe-molecule interactions is crucial for designing functional materials and catalysts.

Purpose of the Study:

To explore the achievable detail and accuracy in quantifying local probe-molecule interaction forces and energies.
To investigate the interaction of a CO2 reduction catalyst, cobalt phthalocyanine (CoPc), with a scanning probe tip on a silver surface.

Main Methods:

Utilized low-temperature, ultrahigh vacuum noncontact atomic force microscopy (NC-AFM).
Recorded force and potential data as a function of tip-surface distance.
Employed a CO molecule at the tip apex for atomic resolution imaging and interaction analysis.

Main Results:

Constructed detailed 3D maps of normal and lateral forces, and tip-molecule interaction potential.
Isolated molecule-tip interactions by analyzing tip-substrate interactions.
Determined atomically resolved equilibrium interaction energies using a Lennard-Jones-type potential model.
Observed physisorption interactions with energies below 160 meV.
Interaction strength varied across the CoPc molecule, being weakest at peripheral hydrogens and strongest around the cobalt center, specifically in surrounding pockets.

Conclusions:

Picometer-accurate SPM can quantitatively map site-specific, distance-dependent probe-molecule interactions.
The study successfully characterized the physisorption interaction of CoPc with a CO-terminated tip, providing insights into catalyst-surface interactions.
The findings demonstrate the potential of NC-AFM for detailed atomic-level characterization of molecular interactions relevant to catalysis and surface chemistry.