Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

532
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
532
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

343
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
343
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

849
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
849
Drug Delivery: Overview01:16

Drug Delivery: Overview

294
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
294

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanoformulations: A Progressive Strategy for Alleviating Migraine through Nasal Route.

CNS & neurological disorders drug targets·2026
Same author

Development and evaluation of intranasal nanostructured lipid carriers encapsulating donepezil HCl and <i>Caesalpinia bonduc</i> seed extract for targeting Alzheimer's disease: <i>in vitro</i> and <i>in vivo</i> evaluation.

Journal of drug targeting·2026
Same author

Fluoxetine HCl-Loaded Nanostructured Lipid Carriers for Nose-to-Brain Delivery: Optimization and Synergistic Role of Saffron Oil.

Journal of molecular neuroscience : MN·2025
Same author

Nanostructured Lipid Carriers of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease.

Current Alzheimer research·2024
Same author

Exploring Potential of Nano-formulations in the Treatment of Alzheimer's Disease through Nasal Route.

Current Alzheimer research·2024
Same author

Nanostructured Lipid Carriers for Nose to Brain Delivery Targeting CNS: Diversified Role of Liquid Lipids for Synergistic Action.

Advanced pharmaceutical bulletin·2022

Related Experiment Video

Updated: Jul 5, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K

Core-Shell Nanoparticles for Pulmonary Drug Delivery.

Mukesh P Ratnaparkhi1, Shailendra S Salvankar1, Avinash R Tekade1

  • 1Department of Pharmaceutics, Marathwada Mitra Mandal's College of Pharmacy, Thergaon, Pune, Maharashtra, 411033, India.

Pharmaceutical Nanotechnology
|January 24, 2024
PubMed
Summary

Core-shell nanoparticles offer superior drug delivery for enhanced therapeutic efficacy and reduced side effects. These advanced systems show great promise for treating various diseases, particularly pulmonary disorders.

Keywords:
Nanoparticlescore-shell nanoparticleslung cancernon-invasive therapypulmonary deliveryrespiratory diseases.

More Related Videos

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.7K

Related Experiment Videos

Last Updated: Jul 5, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.7K

Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmacology

Background:

  • Nanoscale drug delivery systems enhance intracellular drug concentration, improving efficacy and reducing adverse effects.
  • Core-shell nanoparticles exhibit superior biocompatibility, dispersibility, and drug conjugation compared to bare nanoparticles.
  • Pulmonary drug administration is an attractive noninvasive route due to the lung's large surface area and vascularization.

Purpose of the Study:

  • To review the potential of core-shell nanoparticles for treating various diseases, with a focus on pulmonary disorders.
  • To discuss diverse synthesis methods for creating core-shell nanoparticles.
  • To highlight the advantages of core-shell nanoparticle platforms in drug delivery.

Main Methods:

  • Review of existing literature on core-shell nanoparticle applications and synthesis.
  • Discussion of synthesis techniques including solid/liquid/gas phase reactions, mechanical mixing, microwave-assisted, sono-synthesis, and non-thermal plasma.
  • Categorization of core-shell nanoparticles based on core material (metallic, magnetic, polymeric, silica, upconversion, carbon).

Main Results:

  • Core-shell nanoparticles demonstrate enhanced efficacy, reduced cytotoxicity, and improved drug loading and stability.
  • Various synthesis methods allow for tailored nanoparticle properties, including particle size and surface characteristics.
  • Different types of core-shell nanoparticles offer unique advantages for targeted drug delivery.

Conclusions:

  • Core-shell nanoparticles represent a promising platform for advanced drug delivery, particularly for pulmonary diseases.
  • The versatility in synthesis and material composition allows for optimization of drug delivery systems.
  • These systems integrate the benefits of core and shell materials for improved therapeutic outcomes.