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Utilising electrodermal activity sensor signals to quantify nociceptive response during movement activities.

Rebecca I Hamilton1, Ashly Alava Garcia2, Jake Bowd3

  • 1Cardiff University, Cardiff, UK. HamiltonR@cardiff.ac.uk.

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Summary

Electrodermal activity (EDA) shows promise in quantifying pain responses during movement. Skin conductance (SC) significantly increased with noxious stimuli in most activities, revealing gender differences in pain perception.

Keywords:
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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Physiology

Background:

  • The aging population and rising osteoarthritis prevalence necessitate objective measures for pain quantification.
  • Electrodermal activity (EDA), detected via skin conductance (SC) using wearable sensors, offers objective physiological stress response data.
  • Quantifying nociceptive signals during movement can improve treatment and monitoring for painful conditions.

Purpose of the Study:

  • To collect preliminary electrodermal activity (EDA) response data in healthy volunteers during a noxious stimulus protocol.
  • To assess the feasibility of using a defined scenario for protocol testing of nociceptive responses.
  • To investigate potential gender differences in electrodermal activity (EDA) and self-reported pain.

Main Methods:

  • Healthy volunteers underwent a protocol involving various activities while receiving noxious stimuli.
  • Electrodermal activity (EDA) was measured using finger electrodes, focusing on skin conductance (SC) changes.
  • Raw signal extraction, processing, and statistical analysis were performed on mean SC values.

Main Results:

  • A significant average increase in mean skin conductance (SC) was observed in four out of five tested activities (p < 0.05).
  • Significant gender differences were found in both skin conductance (SC) and self-reported pain scores (p < 0.05), with large effect sizes.
  • Limitations include motion artifact sensitivity and a lack of prior movement-based EDA data, restricting analysis.

Conclusions:

  • Electrodermal activity (EDA) parameters show potential as indicators of nociceptive responses during movement.
  • The developed protocol is feasible for testing and demonstrates significant EDA changes related to noxious stimuli.
  • Further refinement of processing pipelines, including signal decomposition, is needed for clinically meaningful nociceptive response quantification.