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A Longitudinal Study of a Selected Pediatric Asthmatic Population with Normal and Abnormal Spirometry at Baseline: An

Sornsiri Yimlamai1, Kanokpan Ruangnapa1, Wanaporn Anuntaseree1

  • 1Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.

Journal of Asthma and Allergy
|January 25, 2024
PubMed

Insights

In children with asthma, abnormal spirometry results were common but did not predict poor outcomes. Adjusting asthma controllers based on symptoms or spirometry yielded similar long-term disease control.

Area of Science:

  • Pediatric Pulmonology
  • Asthma Management
  • Clinical Research

Background:

  • Asthma control in children often relies on clinical assessment.
  • The role of spirometry in guiding asthma controller adjustments in pediatric populations is not well-established.
  • Limited pediatric studies exist on using abnormal spirometry for disease management.

Purpose of the Study:

  • To determine the prevalence of abnormal spirometry in children with asthma.
  • To evaluate the impact of abnormal spirometry on longitudinal asthma outcomes.
  • To assess if spirometry aids in adjusting asthma controller medications in children.

Main Methods:

  • Retrospective cohort study at Songklanagarind Hospital, Thailand.
  • Included children (<18 years) with asthma and spirometry with bronchodilator responsiveness (BDR) tests.
  • Analyzed differences in outcomes between normal and abnormal spirometry groups over 12 months.

Main Results:

  • Abnormal spirometry (airflow limitation or BDR) was found in 58.1% of 203 pediatric asthma patients.
  • No significant differences in baseline characteristics, atopy, treatment, or outcomes between spirometry groups.
  • Adjustments based on spirometry or symptoms led to comparable 12-month disease control.

Conclusions:

  • Abnormal spirometry is prevalent in treated school-aged children with asthma.
  • Abnormal spirometry did not correlate with poorer asthma outcomes in the follow-up period.
  • Symptom-based and spirometry-based controller adjustments achieved similar asthma control.
Abstract

Keywords:
bronchodilator responsivenesschildhood asthmalung function testpulmonary function test

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