Related Experiment Video
Updated: Jul 5, 2025

07:31
Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
6.0K
DNA nanocrane-based catalysts for region-specific protein modification
Jordi F Keijzer1, Bauke Albada1
1Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. bauke.albada@wur.nl.
Organic & Biomolecular Chemistry
|January 25, 2024
Abstract:
This paper describes the development and performance of catalytic DNA-based nanocranes for the controlled modification of wild-type proteins. We show that the position of the catalyst offers control over the region of modification, and that reversible interactions between the catalytic structure and thrombin enable trigger-responsive modification, even in cell lysate.

