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Updated: Jul 5, 2025

The Use of Fluorescent Target Arrays for Assessment of T Cell Responses In vivo
Published on: June 19, 2014
The Functional Assessment of T Cells
1Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. saho@m.ehime-u.ac.jp.
Abstract:
It is important to know what kind of T-cell populations are involved in various disease states, and to know the state of T-cell functions involving in the disease. When a T cell's antigen receptors (TCR) recognize a specific antigen, the cell transmits a signal by a transduction mechanism within the T cell's cytoplasm. This signal initiates gene transcription essential for differentiation and activation of T cells. In this chapter, we will describe the methods of analyzing the transcribed mRNA and detecting the translated product in order to know the activation state of T cells.
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