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Evolution and multiple functions of sulfonation and cytosolic sulfotransferases across species
Katsuhisa Kurogi1, Masahito Suiko1, Yoichi Sakakibara1
1Department of Biochemistry and Applied Biosciences, University of Miyazaki, Miyazaki, Japan.
Abstract:
Organisms have conversion systems for sulfate ion to take advantage of the chemical features. The use of biologically converted sulfonucleotides varies in an evolutionary manner, with the universal use being that of sulfonate donors. Sulfotransferases have the ability to transfer the sulfonate group of 3'-phosphoadenosine 5'-phosphosulfate to a variety of molecules. Cytosolic sulfotransferases (SULTs) play a role in the metabolism of low-molecular-weight compounds in response to the host organism's living environment. This review will address the diverse functions of the SULT in evolution, including recent findings. In addition to the diversity of vertebrate sulfotransferases, the molecular aspects and recent studies on bacterial and plant sulfotransferases are also addressed.
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