Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Features, Antimicrobial Susceptibilities, and Outcomes of Acute-Onset Exogenous Nocardia Endophthalmitis.

Journal of vitreoretinal diseases·2026
Same author

Antiseptic Efficacy and Ocular Surface Toxicity of Povidone-Iodine and Chlorhexidine for Endophthalmitis Isolates.

Investigative ophthalmology & visual science·2026
Same author

Genetic Testing in Inherited Retinal Disease: Current Strategies and Future Directions.

Journal of personalized medicine·2026
Same author

Exogenous Fusarium Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes.

Investigative ophthalmology & visual science·2026
Same author

Endophthalmitis caused by gram-negative bacteria: etiologies, antibiotic susceptibilities, and treatment outcomes.

Journal of ophthalmic inflammation and infection·2026
Same author

Postoperative Fungal Endophthalmitis Associated With Trypan Blue Use During Cataract Surgery.

JAMA ophthalmology·2026

Related Experiment Video

Updated: Jul 5, 2025

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.7K

OUTCOMES OF INFECTIOUS PANUVEITIS ASSOCIATED WITH SIMULTANEOUS MULTI-POSITIVE OCULAR FLUID POLYMERASE CHAIN REACTION.

Viet Q Chau1, John W Hinkle1,2, Chris Y Wu1,3

  • 1University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida.

Retina (Philadelphia, Pa.)
|January 25, 2024
PubMed
Summary

Multiple pathogens in ocular fluid, including cytomegalovirus (CMV) and Epstein-Barr virus (EBV), were detected in infectious panuveitis cases. CMV-positive eyes showed better visual outcomes than CMV-negative eyes in this study.

More Related Videos

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

4.8K
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

11.4K

Related Experiment Videos

Last Updated: Jul 5, 2025

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.7K
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

4.8K
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

11.4K

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Molecular Diagnostics

Background:

  • Infectious panuveitis can be caused by various pathogens.
  • Ocular fluid sampling and polymerase chain reaction (PCR) enable pathogen detection.
  • Understanding the features of multi-pathogen infections is crucial for patient management.

Purpose of the Study:

  • To evaluate the clinical features of infectious panuveitis associated with multiple pathogens detected by ocular fluid sampling.
  • To identify common pathogens involved in co-infections.
  • To assess visual acuity outcomes in relation to specific pathogens.

Main Methods:

  • Retrospective analysis of a single-center, consecutive case series.
  • Aqueous and vitreous samples were tested using multiplex PCR.
  • Data collected included pathogen identification, clinical features, and visual acuity.

Main Results:

  • 28 (1.76%) of 1,588 PCR samples were positive for multiple pathogens.
  • Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) were the most common pathogens.
  • Patients with co-infections were often immunosuppressed, with high rates of retinal detachment and poor visual acuity. CMV-positive eyes had better final visual acuity (P < 0.05).

Conclusions:

  • CMV and EBV are frequently identified in multi-pathogen infectious panuveitis.
  • Co-infections are associated with immunosuppression, retinal detachment, and poor visual outcomes.
  • CMV presence correlates with improved visual outcomes compared to its absence in multi-pathogen cases.