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Drug therapies for obstructive sleep apnoea: a systematic review and meta-analysis protocol
Maria Luisa Nobre1,2, Ayane Cristine Alves Sarmento2,3, Kleyton Santos Medeiros4
1Surgery Department, Federal University of Rio Grande do Norte, Natal, Brazil.
BMJ Open
|January 25, 2024
Summary
This systematic review examines drug therapies for obstructive sleep apnoea (OSA). It synthesizes evidence on treatment efficacy and safety to inform clinical practice for this common sleep disorder.
Area of Science:
- Sleep Medicine
- Pharmacology
- Clinical Research
Background:
- Obstructive sleep apnoea (OSA) significantly impacts quality of life and increases risks for serious health conditions.
- Current evidence on drug therapies for OSA is limited, highlighting a critical knowledge gap.
- Pharmacological interventions are being explored as potential alternatives for OSA management.
Purpose of the Study:
- To systematically evaluate the efficacy and safety of pharmacological treatment options for patients diagnosed with OSA.
- To synthesize current evidence on drug therapies for OSA using a comprehensive systematic review methodology.
Main Methods:
- A comprehensive search of multiple databases (PubMed, Embase, Web of Science, etc.) was conducted for relevant clinical trials.
- Studies were screened for polysomnographic outcomes (Apnoea-Hypopnoea index) and secondary outcomes like daytime sleepiness and adverse events.
- Data synthesis and risk of bias assessment were performed using Cochrane Risk of Bias Tool and Review Manager V.5.4.1.
Main Results:
- This section is to be populated upon completion of the systematic review and data analysis.
- Results will detail the efficacy and safety profiles of various drug therapies investigated for OSA.
- The strength of evidence for each intervention will be assessed using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach.
Conclusions:
- This systematic review will provide crucial insights into the effectiveness and safety of drug therapies for OSA.
- Findings will inform clinical decision-making and guide future research in pharmacological treatments for OSA.
- The study aims to address the current lack of robust evidence regarding drug interventions for OSA patients.
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