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Senile Cataract Formation Does Not Affect Crystalline Lens Thickness.

Alberto López-de la Rosa1,2, Cecilia Díez-Montero1,3, Elena Martínez-Plaza1

  • 1Instituto de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Paseo de Belén 17, 47011, Valladolid, Spain.

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|January 25, 2024
PubMed
Summary

Senile cataracts do not significantly alter lens thickness (LT), anterior (ACS) and posterior (PCS) cortex space, or nuclear thickness (NT) when confounding factors like age and sex are controlled. Further research should account for these variables in lens measurements.

Keywords:
CataractCorticalLensNuclearSubcapsularThickness

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering

Background:

  • Accurate characterization of lens thickness (LT) is crucial for understanding lens aging and improving intraocular lens (IOL) power calculations.
  • Senile cataracts, a common age-related condition, may influence ocular biometric parameters.

Purpose of the Study:

  • To investigate the impact of senile cataract formation on LT, anterior (ACS) and posterior (PCS) cortex space, and nuclear thickness (NT).
  • To control for potential confounding factors including sex, age, and axial length in the analysis.

Main Methods:

  • A cross-sectional study involving 603 volunteers (aged 59.1 ± 18.8 years) was conducted.
  • Eyes were classified using the Lens Opacification Classification System (LOCS)-III for cataract presence and type (cortical, nuclear, posterior subcapsular).
  • Optical biometry measured LT, ACS, NT, and PCS, with propensity score matching used to control for covariates.

Main Results:

  • Unmatched cataractous eyes showed significantly higher LT, ACS, NT, and PCS compared to non-cataractous eyes.
  • After propensity score matching for sex, age, and axial length, no significant differences were found in LT, ACS, NT, or PCS between cataractous and non-cataractous groups.
  • Specifically, matched LT (4.34 vs. 4.33 mm, p=0.94), ACS (0.72 vs. 0.76 mm, p=0.08), NT (3.31 vs. 3.30 mm, p=0.24), and PCS (0.42 vs. 0.43 mm, p=0.79) showed no significant variation.

Conclusions:

  • The presence of senile cortical, nuclear, and posterior subcapsular cataracts does not independently affect lens thickness (LT), anterior (ACS) and posterior (PCS) cortex space, or nuclear thickness (NT).
  • Controlling for confounding factors such as sex, age, and axial length is essential when analyzing LT and its components.