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Solid-State Nanopores for Biomolecular Analysis and Detection.

Annina Stuber1, Tilman Schlotter1, Julian Hengsteler1

  • 1Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zürich, Zürich, Switzerland.

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Summary

Solid-state nanopores offer a stable, controllable alternative to biological nanopores for DNA sequencing. This review explores innovations in solid-state nanopore fabrication and applications in biomolecular analysis and detection.

Keywords:
AptamersBiosensingDNA origamiGenomicsIonic currentMultiomicsProteomicsRNASequencingSingle molecule

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Area of Science:

  • Nanotechnology
  • Biomolecular analysis
  • Biosensing

Background:

  • Biological nanopores used in DNA sequencing have limitations, including specific environmental requirements.
  • Solid-state nanopores are emerging as a promising alternative due to their modularity and controllable characteristics.
  • These solid-state systems can operate in non-physiological conditions, expanding their application scope.

Purpose of the Study:

  • To review recent innovations in solid-state nanopore technology.
  • To explore the potential of solid-state nanopores for advanced biomolecular analysis and detection.
  • To provide an outlook on the future frontiers of nanopore technologies.

Main Methods:

  • Review of physical aspects of nanopore measurements, including interfacial interactions, mass transport, and signal analysis.
  • Examination of nanopore fabrication and post-processing techniques, evaluating pros and cons.
  • Analysis of progress in DNA sequencing using solid-state nanopores and its evolution towards protein sequencing.

Main Results:

  • Solid-state nanopores demonstrate significant advancements in fabrication and functionality.
  • The technology shows promise for DNA sequencing and is progressing towards protein sequencing.
  • Recent developments in biosensing of nucleic acids, proteins, and sugars using solid-state nanopores are highlighted.

Conclusions:

  • Solid-state nanopores represent a significant advancement over biological counterparts for various applications.
  • The technology is evolving rapidly, offering new possibilities for sensitive and versatile biomolecular detection.
  • Future research directions point towards expanded capabilities in complex biological analyses and diagnostics.