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Variation in the basal immune state and implications for disease
Aisha Souquette1, Paul G Thomas1
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States.
Elife
|January 26, 2024
Summary
Investigating the baseline immune state (I₀) is crucial for understanding infection susceptibility beyond memory responses. This review explores I₀ determinants and its impact on influenza, offering a framework for modeling immune competence.
Area of Science:
- Immunology
- Infectious Disease Modeling
- Systems Biology
Background:
- Immune memory responses are typically studied in isolation.
- Leukocyte function is influenced by the broader immune environment and non-antigen-specific factors.
- The composite basal state of the immune system (I₀) significantly impacts immune cell function.
Conclusions:
- Understanding I₀ is vital for comprehending immune variation and infection outcomes.
- Modeling I₀ can aid in identifying at-risk populations.
- Insights into I₀ can inform the development of broad-spectrum prophylactic and therapeutic strategies.
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