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Updated: Jun 13, 2026

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Emerging Multiscale Biofabrication Approaches for Bacteriotherapy.

Roberta Rovelli¹, Beatrice Cecchini¹, Lorenzo Zavagna²

¹Department of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy.

Molecules (Basel, Switzerland)

|January 26, 2024

Summary

Bacteriotherapy uses beneficial bacteria to combat infections. This review explores advanced biomaterial strategies, particularly hydrogels, for delivering these microbes and their byproducts effectively.

Keywords:

3D printing electrospinning electrospray polysaccharides probiotics sodium alginate tissue engineering

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Author Spotlight: Studying Bacterial Growth in 3D Hydrogel Matrices

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Published on: January 19, 2024

Area of Science:

Biomaterials Science
Microbiology
Drug Delivery

Background:

Bacteriotherapy, utilizing probiotics, offers a promising strategy against infections and dysbiosis.
Effective delivery of probiotics and post-biotics is crucial for therapeutic success.
Biomaterial encapsulation presents innovative solutions for controlled delivery.

Purpose of the Study:

To review recent biomaterial-assisted strategies for bacteriotherapy in treating infections and dysbiosis.
To detail multiscale biomaterial approaches for probiotic encapsulation.
To highlight the role of hydrogels and advanced fabrication techniques.

Main Methods:

Review of literature on biomaterial encapsulation for bacteriotherapy.
Analysis of hydrogel-based systems across different dimensions (0D, 1D, 2D, 3D).
Investigation of biofabrication methods like electrospinning, electrospray, and 3D bioprinting.

Main Results:

Hydrogels, especially polysaccharide-based, show potential for sustaining probiotic viability.
Multidimensional biomaterial constructs (particles, fibers, scaffolds) offer diverse therapeutic applications.
Advanced fabrication techniques enable precise probiotic encapsulation within matrices.

Conclusions:

Biomaterial encapsulation is key to advancing bacteriotherapy for infections and dysbiosis.
Hydrogel-based systems and novel fabrication methods are critical for effective probiotic delivery.
Future research should focus on optimizing these systems for enhanced therapeutic outcomes.