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Related Experiment Video

Updated: Jul 4, 2025

Calcium Carbonate Formation in the Presence of Biopolymeric Additives
09:31

Calcium Carbonate Formation in the Presence of Biopolymeric Additives

Published on: May 14, 2019

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Microfluidically Assisted Synthesis of Calcium Carbonate Submicron Particles with Improved Loading Properties.

Alexey V Ermakov1, Sergei V Chapek2, Ekaterina V Lengert1

  • 1Institute of Molecular Theranostics, First Moscow State Medical University, 119991 Moscow, Russia.

Micromachines
|January 26, 2024
PubMed
Summary

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This summary is machine-generated.

Microfluidic synthesis of submicron calcium carbonate particles offers enhanced porosity and peptide loading capacity. These biocompatible particles show promise for advanced drug delivery systems.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Advanced synthesis methods for nano- and microparticles are crucial in biomedicine.
  • Existing methods face challenges in efficiency, scalability, and particle uniformity.
  • Submicron particles are desirable for applications like drug delivery.

Purpose of the Study:

  • To investigate the microfluidic synthesis of submicron calcium carbonate particles.
  • To control particle formation and properties using a T-shaped oil supply microfluidic chip.
  • To evaluate particle porosity, peptide loading, and biosafety.

Main Methods:

  • Droplet-based synthesis using a microfluidic chip with a T-shaped oil supply.
  • Precise manipulation of reaction parameters for controlled particle formation.
Keywords:
advanced synthesis methodsbiomedicinedrug delivery applicationsmicrofluidic chipnano- and microparticlesparticle morphologysubmicron calcium carbonate

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  • Small-angle X-ray scattering (SAXS) for pore size distribution analysis.
  • Cytotoxicity studies using mouse fibroblasts to assess biosafety.

    • Main Results:

    • Achieved controlled synthesis of submicron calcium carbonate particles with enhanced porosity.
    • Demonstrated significantly higher model peptide loading (16 mass.%) in microfluidically synthesized particles compared to bulk synthesis (9 mass.%).
    • Established biosafety of the particles within the tested concentration range (0.08-0.8 mg/plate).

    Conclusions:

    • Microfluidic chip-based synthesis enables efficient production of highly porous submicron calcium carbonate particles.
    • The developed particles exhibit superior drug loading capabilities, beneficial for drug delivery.
    • This microfluidic approach presents a promising platform for synthesizing particles for biomedical applications.