Related Experiment Video

Updated: Jul 4, 2025

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
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All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

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LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization

Feng Zhang1, Mohammed Awal Issah2, Hai-Ying Fu3

  • 1Fujian Provincial Key Laboratory on Hematology, Fujian Medical Center of Hematology, Fujian Institute of Hematology, Clinical Research Center for Hematological Malignancies of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, 350001, China.

Current Medical Science
|January 26, 2024
PubMed
Summary

YAP1's role in B cell acute lymphoblastic leukemia (B-ALL) was explored. High YAP1 expression with low phosphorylation correlated with poor prognosis, suggesting VP targeting this axis for B-ALL therapy.

Keywords:
RNA-SeqYes1-associated proteinacute lymphoblastic leukemialarge tumor suppressor kinase 1phosphorylation

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