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Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
Working Memory Training Responsiveness in Parkinson's Disease Is Not Determined by Cortical Thickness or White Matter
Kathrin Giehl1,2, Hendrik Theis1,3, Anja Ophey4
1Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Multimodal Neuroimaging Group, Cologne, Germany.
Abstract:
Patients with Parkinson's disease are highly vulnerable for cognitive decline. Thus, early intervention by means of working memory training (WMT) may be effective for the preservation of cognition. However, the influence of structural brain properties, i.e., cortical thickness and volume of white matter lesions on training responsiveness have not been studied. Here, behavioral and neuroimaging data of 46 patients with Parkinson's disease, 21 of whom engaged in home-based, computerized adaptive WMT, was analyzed. While cortical thickness and white matter lesions volume were associated with cognitive performance at baseline, these structural brain properties do not seem to determine WMT responsiveness.
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