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Updated: Jul 4, 2025

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Systemic Immune Modulation by Gastrointestinal Nematodes.

Darshan N Kasal¹, Lindsey M Warner¹, Astra S Bryant²

¹Department of Immunology, University of Washington, Seattle, Washington, USA;

Annual Review of Immunology

|January 26, 2024

Summary

This summary is machine-generated.

Gastrointestinal nematode infections impact the immune system beyond the gut. This review explores how these infections alter systemic immunity and affect overall health and disease resistance.

Keywords:

helminth infection host–parasite interaction mucosal immunity type 2 immunity

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Experimental Infection of Mice with the Parasitic Nematode Strongyloides ratti ratti Infection

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Area of Science:

Immunology
Parasitology
Microbiome Research

Background:

Gastrointestinal nematode (GIN) infections exert evolutionary pressure on mammalian immunity.
GIN infections pose a significant global health and economic challenge.
While primarily intestinal, GIN infections influence immune states in distal tissues.

Purpose of the Study:

To review how GIN infections modulate systemic immunity.
To discuss the mechanisms by which GINs affect distal tissues.
To highlight the consequences of GIN-induced immune changes on health and disease.

Main Methods:

Review of existing literature on GIN immunology.
Analysis of host-parasite interactions.
Examination of immune responses in both intestinal and distal tissues.

Main Results:

GIN infections induce host resistance and tolerance.
Parasites secrete immunomodulatory products.
GINs interact with the gut microbiome, influencing systemic immunity.

Conclusions:

GIN infections have far-reaching systemic effects on immunity.
Distal immune changes impact concurrent/subsequent infections and chronic diseases.
Understanding these systemic effects is crucial for public health and vaccination strategies.