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Stimuli-responsive biodegradable silica nanoparticles: From native structure designs to biological applications
Qianhui Qi1, Qian Shen2, Jiaying Geng2
1School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China; Future Food Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing 314100, China.
Advances in Colloid and Interface Science
|January 26, 2024
Summary
Biodegradable silica nanoparticles (SiNPs) offer promising biomedical applications. This review highlights multi-stimuli responsive SiNPs designed for efficient in vivo degradation and clearance, addressing toxicity concerns for nanomedicine.
Area of Science:
- Biomaterials Science
- Nanomedicine
- Biotechnology
Background:
- Silica nanoparticles (SiNPs) show great potential in biosensors and biomedicine due to their advantages.
- However, long-term accumulation and nonspecific distribution of SiNPs in healthy tissues can lead to toxicity, limiting clinical use.
- Developing biodegradable and clearable SiNPs is crucial for safe biomedical applications.
Purpose of the Study:
- To comprehensively review the rational design and recent advancements in biodegradable SiNPs.
- To focus on SiNPs responsive to multiple stimuli for enhanced in vivo degradation and clearance.
- To discuss factors influencing SiNP biodegradation for improved nanomedicine and nanosensor development.
Main Methods:
- Systematic review of literature on stimuli-responsive biodegradable SiNPs.
- Analysis of design strategies for enhancing SiNP degradation under pathological conditions.
- Discussion of factors affecting SiNP biodegradation kinetics and pathways.
Main Results:
- Multi-stimuli responsive SiNPs demonstrate improved degradation efficiency in specific pathological environments.
- Designed biodegradable SiNPs facilitate rapid in vivo degradation and clearance, mitigating toxicity risks.
- Understanding factors influencing biodegradation is key to optimizing SiNP performance.
Conclusions:
- Biodegradable and stimuli-responsive SiNPs are essential for advancing theranostic nanoplatforms.
- This review provides a guide for future research in SiNP-based nanosensors and nanomedicine.
- Optimized SiNP design can overcome current limitations, paving the way for broader clinical translation.
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