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Related Concept Videos

Ankle Joint01:10

Ankle Joint

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The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
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Related Experiment Video

Updated: Jul 4, 2025

Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability
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Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability

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Chronic Ankle Joint Instability Induces Ankle Sensorimotor Dysfunction: A Controlled Laboratory Study.

Sora Kawabata1,2, Kaichi Ozone1,3, Yuki Minegishi1,4

  • 1Department of Health and Social Services, Health and Social Services, Graduate School of Saitama Prefectural University, Saitama, Japan.

The American Journal of Sports Medicine
|January 27, 2024
PubMed
Summary

Ankle instability leads to mechanoreceptor degeneration and reduced sensory neuron sensitivity, contributing to chronic ankle instability (CAI). Early intervention after ankle sprains is crucial to prevent CAI development.

Keywords:
ankleligamentsphysical therapy

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Area of Science:

  • Biomechanics
  • Neuroscience
  • Orthopedics

Background:

  • Chronic ankle instability (CAI) often follows ankle sprains, leading to recurrent injuries due to sensorimotor dysfunction.
  • The precise mechanisms underlying CAI pathogenesis after initial ligament injury remain incompletely understood.

Purpose of the Study:

  • To investigate the role of mechanoreceptor degeneration and altered mechanosensitivity in the development of CAI using an animal model.
  • To elucidate the relationship between ankle instability, mechanoreceptor integrity, and sensorimotor function.

Main Methods:

  • Ankle joint instability (AJI) was surgically induced in Wistar rats by transecting the calcaneofibular ligament.
  • Ankle instability, sensorimotor function (ladder walking, balance beam), mechanoreceptor morphology (S100, neurofilament), and PIEZO2 expression were assessed postoperatively.
  • Histological analysis of the anterior talofibular ligament (ATFL) mechanoreceptors and sensory neuron mechanosensitivity was performed.

Main Results:

  • Rats with induced ankle instability showed decreased sensorimotor function and increased ankle instability compared to controls.
  • A significant reduction in ATFL mechanoreceptor number and decreased PIEZO2 expression in sensory neurons were observed in the AJI group.
  • The number of mechanoreceptors was negatively correlated with the degree of sensorimotor dysfunction.

Conclusions:

  • The developed AJI model replicates key features of CAI, including mechanoreceptor degeneration and reduced neuronal mechanosensitivity.
  • These findings suggest that damage to mechanoreceptors and impaired mechanosensation are critical factors in the pathogenesis of chronic ankle instability.