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Profound acidosis caused by isoniazid ingestion
The American Journal of Emergency Medicine
|March 1, 1987
Summary
Isoniazid (INH) overdose can cause severe metabolic acidosis. A patient survived an extremely low pH of 6.49, marking the lowest reported pH with survival in INH toxicity cases.
Area of Science:
- Toxicology
- Emergency Medicine
- Pharmacology
Background:
- Isoniazid (INH) is a primary treatment for tuberculosis and a common cause of drug overdose.
- INH overdose can lead to severe metabolic acidosis, a life-threatening condition.
Observation:
- A case of severe isoniazid (INH) overdose is presented.
- The patient presented with an extremely low arterial pH of 6.49, indicative of profound metabolic acidosis.
- Remarkably, the patient survived this overdose without apparent long-term sequelae.
Findings:
- This case represents the lowest reported pH level (6.49) associated with patient survival following an overdose.
- The study discusses the complex toxicity and pharmacology of isoniazid.
- Key aspects of managing severe metabolic acidosis in the context of INH overdose are explored.
Implications:
- This case highlights the potential for survival even in extremely severe isoniazid-induced metabolic acidosis.
- It underscores the importance of aggressive supportive care in managing drug overdose toxicity.
- Further research into the mechanisms of tolerance and recovery from profound acidosis may inform treatment strategies.