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Updated: Jul 4, 2025

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture

Published on: December 26, 2017

Generating dual structurally and functionally skin-mimicking hydrogels by crosslinking cell-membrane compartments.

Feng Wu^1,2, Yusheng Ren^1,2, Wenyan Lv^2,3

¹Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.

Nature Communications

|January 27, 2024

Summary

Researchers created advanced skin-mimicking hydrogels by crosslinking cell-membrane compartments. These biomaterials offer enhanced mechanical strength, antibacterial properties, and immune cell activation for versatile applications.

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Last Updated: Jul 4, 2025

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Area of Science:

Biomaterials Science
Tissue Engineering
Polymer Chemistry

Background:

The skin acts as a natural hydrogel, providing mechanical strength, antimicrobial defense, and immune functions.
Developing synthetic hydrogels that mimic both skin's structure and function remains a significant challenge.

Purpose of the Study:

To engineer dual structurally and functionally skin-mimicking hydrogels.
To utilize cell-membrane compartments as building blocks for advanced biomaterials.

Main Methods:

Crosslinking of extracellular vesicles (EVs) functionalized with olefinic double bonds via free radical polymerization.
Formation of a compartment-crosslinked network exhibiting enhanced mechanical properties.
Introduction of a secondary network using catalyst-free click chemistry between polymers and azido-decorated EVs.

Main Results:

The compartment-crosslinked hydrogels demonstrated superior mechanical strength due to vesicular deformation, surpassing conventional divinyl monomer crosslinking.
The biomimetic hydrogels exhibited antibacterial activity and promoted dendritic cell maturation and activation.
The platform allowed for tunable control over both the structure and function of the resulting skin-inspired hydrogels.

Conclusions:

This study presents a novel platform for creating skin-mimicking hydrogels with controllable dual structures and functions.
The developed biomaterials hold potential for applications in tissue engineering and regenerative medicine.
The use of extracellular vesicles as crosslinkers offers a promising strategy for advanced biomaterial design.