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Updated: Jul 4, 2025
12:12
In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
Published on: December 17, 2013
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Inducing Pluripotency in Somatic Cells: Historical Perspective and Recent Advances
Junmyeong Park1, Jueun Kim1, Borami Shin2
1Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea.
International Journal of Stem Cells
|January 28, 2024
Summary
Induced pluripotent stem cells (iPSCs) offer promise for regenerative medicine and disease modeling. This review covers iPSC generation history and recent advances, noting low efficiency remains a challenge.
Area of Science:
- Stem cell biology
- Regenerative medicine
- Genetics
Background:
- Somatic cell reprogramming into induced pluripotent stem cells (iPSCs) is mediated by Yamanaka factors.
- iPSCs possess potential for regenerative medicine and patient-specific disease modeling.
- Patient-derived iPSCs can be genetically corrected for therapeutic applications.
Purpose of the Study:
- To review the historical timeline of discoveries leading to iPSC generation.
- To discuss recent advancements in iPSC technology.
- To highlight various donor cell types used in iPSC generation.
Main Methods:
- Review of scientific literature on iPSC generation.
- Historical analysis of key discoveries.
- Discussion of recent technological advances and donor cell types.
Main Results:
- The efficiency of iPSC generation is still low and variable.
- Different donor cell types impact reprogramming efficiency.
- Significant progress has been made in iPSC technology development.
Conclusions:
- iPSC technology holds significant promise for disease modeling and regenerative medicine.
- Further research is needed to improve reprogramming efficiency.
- Understanding donor cell type influence is crucial for optimizing iPSC generation.
Keywords:
Cellular reprogrammingEmbryonic stem cellsInduced pluripotent stem cellsOctamer-binding transcription factor 4 (OCT4)PluripotencyMore Related Videos
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