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Updated: Jul 4, 2025
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Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
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Genetics in Parkinson's disease, state-of-the-art and future perspectives
L Trevisan1,2, A Gaudio3, E Monfrini4,5
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Largo P. Daneo 3, Genova, 16132, Italy.
British Medical Bulletin
|January 28, 2024
Summary
Genetic factors significantly impact Parkinson's disease (PD) progression and treatment response. Polygenic Risk Scores (PRS) offer a promising approach for personalized PD care and risk stratification.
Area of Science:
- Neurogenetics
- Neurodegenerative Disorders
- Personalized Medicine
Background:
- Parkinson's disease (PD) is a common neurodegenerative disorder with diverse motor and non-motor symptoms.
- While the exact cause of PD is unknown, monogenic forms represent a small but significant etiological factor.
Approach:
- This review synthesizes current knowledge on the genetic underpinnings of Parkinson's disease.
- It examines the role of genetic variants in disease onset, progression, and therapeutic response.
Key Points:
- Approximately 15% of PD patients harbor pathogenic variants in PD-associated genes, influencing disease trajectory.
- Genetic testing has clinical implications for prognosis and treatment but lacks standardized guidelines.
- Challenges remain in confirming new genetic associations and selecting genes for diagnostic panels.
Conclusions:
- Polygenic Risk Scores (PRS) show potential for stratifying individuals based on PD risk, prognosis, and treatment outcomes.
- Integrating PRS and multi-omics data may enhance personalized care strategies for Parkinson's disease patients.
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