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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Base Excision Repair01:54

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Cell Population Analyses During Skin Carcinogenesis
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Exposome and basal cell carcinoma: a multicenter case-control study.

Alba Navarro-Bielsa1, Tamara Gracia-Cazaña1, Manuel Almagro2

  • 1Department of Dermatology, Hospital Universitario Miguel Servet, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain.

International Journal of Dermatology
|January 29, 2024
PubMed
Summary

Basal cell carcinoma (BCC) risk is linked to more than just sun exposure. Factors like outdoor work, certain medications, and diet also play a role, highlighting the need for comprehensive prevention strategies.

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Area of Science:

  • Dermatology and Environmental Health
  • Epidemiology of Skin Cancer
  • Exposome Research

Background:

  • Ultraviolet radiation (UVR) is the primary cause of skin cancer, particularly basal cell carcinoma (BCC).
  • Other environmental and lifestyle factors (exposome) may also contribute to BCC development.
  • The Spanish population's specific risk factors for BCC require further investigation.

Purpose of the Study:

  • To investigate the association between basal cell carcinoma (BCC) and various exposome-related factors.
  • To identify specific risk factors beyond chronic sun exposure in the Spanish population.
  • To inform primary prevention strategies for BCC.

Main Methods:

  • Prospective multicenter case-control study conducted in Spain.
  • Recruited 119 BCC cases and 127 controls between April 2020 and August 2022.
  • Data collected by 13 dermatologists on exposome factors, lifestyle, and medical history.

Main Results:

  • BCC cases showed higher rates of outdoor work, longer UVR exposure, and increased use of specific medications (statins, ASA, hydrochlorothiazide, ACE inhibitors, omeprazole).
  • Dietary factors linked to BCC included higher linolenic acid intake and lower coffee consumption.
  • While sun avoidance was common, BCC patients used lower SPF sunscreen historically and higher rates of hats/caps.

Conclusions:

  • Basal cell carcinoma (BCC) is significantly associated with multiple exposome factors beyond chronic sun exposure in Spain.
  • Primary prevention should focus on outdoor workers, promoting sun safety, stress reduction, and adequate photoprotection for those on specific medications.
  • Understanding the interplay of exposome factors is crucial for effective BCC risk management.