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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Imaging and spatial omics of kidney injury: significance, challenges, advances and perspectives

Zehua Li1,2,3, Yao Lu1,2,3, Li Yang1,2,3

  • 1Renal Division, Peking University Institute of Nephrology, Peking University First Hospital, Beijing, China.

Medical Review (2021)
|January 29, 2024
PubMed

Insights

Early detection and treatment of kidney injury are vital, but complex renal structures hinder diagnosis. Integrating advanced imaging and omics technologies offers a promising path toward understanding and treating kidney diseases.

Area of Science:

  • Nephrology and biomedical imaging.
  • Molecular biology and systems biology.

Background:

  • Kidney injury (KI) poses significant health challenges, necessitating early diagnosis and effective treatments.
  • The intricate structure and function of kidneys complicate early detection and comprehensive evaluation of KI.
  • Current understanding of KI pathogenesis is limited by complex mechanisms, hindering successful drug development.

Purpose of the Study:

  • To highlight recent advances in renal imaging and omics for kidney injury research.
  • To address the challenges in creating a comprehensive cellular and molecular atlas of kidney injury.
  • To emphasize the need for multimodal integration technologies for a systematic understanding of nephropathy.

Main Methods:

  • Utilizing high-resolution structural atlases of the kidney.
  • Employing dynamic and non-invasive evaluation of renal function.
  • Establishing spatially resolved molecular atlases through transcriptomics and metabolomics.

Main Results:

  • Recent progress in renal imaging and omics provides new insights into kidney injury.
  • Multimodal integration of imaging and omics technologies are being explored to overcome single-modality limitations.
  • These approaches aim for a systematic description of nephropathy mechanisms.

Conclusions:

  • Further extensive research in renal multimodal imaging and omics is crucial.
  • Deepening the understanding of kidney injury from diagnostic, mechanistic, and therapeutic perspectives is essential.
  • Developing integrated approaches will advance the diagnosis, treatment, and prevention of kidney diseases.
Keywords:
imagingkidney injurymulti-modalitiesomics

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