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Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Updated: Jun 23, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Speculum-free portable preterm imaging system.

Tananant Boonya-Ananta¹, Mariacarla Gonzalez¹, Ajmal Ajmal¹

¹Florida International University, Department of Biomedical Engineering, Miami, Florida, United States.

Journal of Biomedical Optics

|January 29, 2024

Summary

This summary is machine-generated.

A new portable preterm imaging system (PPRIM) offers speculum-free cervical imaging using polarized light. This innovation aims to improve preterm birth risk assessment and enhance maternal and infant health outcomes.

Keywords:

Mueller-matrix polarized imaging portable device pregnancy preterm labor

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Area of Science:

Biomedical Engineering
Medical Imaging
Obstetrics & Gynecology

Background:

Preterm birth before 37 weeks of gestation is a leading cause of infant mortality and lifelong developmental impairment.
Current diagnostic tools for preterm birth risk are limited, hindering patient care and therapeutic development.

Purpose of the Study:

To develop a speculum-free, portable preterm imaging system (PPRIM) for cervical imaging.
To test the PPRIM's capability for polarization analysis of cervical images in healthy volunteers.

Main Methods:

The PPRIM utilizes Mueller-matrix imaging with a polarized imaging probe and a flexible, comfortable insertable sheath.
The system was tested for high-resolution imaging, polarization properties of birefringent samples, and visualization of the cervix.

Main Results:

The PPRIM achieved high-resolution imaging (20 mm working distance, 25 mm field of view).
The system successfully resolved birefringent sample orientation and captured full-field images of a healthy, non-pregnant cervix.
The device meets design specifications for portability, comfort, and ease of use.

Conclusions:

The PPRIM offers a novel approach to cervical imaging using polarized Mueller-matrix imaging.
This technology has the potential to improve access to care, reduce maternal and infant mortality, and enhance women's reproductive health outcomes.