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Zebrafish Experimental Animal Models for AD: A Comprehensive Review
Ruksar Sande1, Angel Godad1, Gaurav Doshi1
1Department of Pharmacology, Toxicology and Therapeutics, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, V L M Road, Vile Parle (w), Mumbai, 400056, India.
Current Reviews in Clinical and Experimental Pharmacology
|January 29, 2024
Summary
Zebrafish models offer a cost-effective alternative for studying Alzheimer's disease (AD) pathogenesis. This review highlights how neurotoxic agents and transgenic zebrafish replicate AD, aiding in the development of new therapies.
Area of Science:
- Neuroscience
- Genetics
- Pharmacology
Background:
- Alzheimer's disease (AD) is a complex neurodegenerative disorder marked by neurofibrillary tangles and amyloid plaques.
- Current transgenic AD models are valuable but present significant cost and time challenges in preclinical research.
Purpose of the Study:
- To review the utility of zebrafish as a complementary model for Alzheimer's disease research.
- To explore molecular mechanisms of neurotoxicity and cognitive impairment in zebrafish relevant to AD.
Main Methods:
- Review of studies using neurotoxic agents (okadaic acid, cigarette smoke extract, metals) in zebrafish.
- Analysis of transgenic zebrafish models genetically similar to human AD patients.
- Examination of molecular pathways (glutamatergic, cholinergic) involved in learning and memory.
Main Results:
- Neurotoxic agents and genetic modifications in zebrafish can induce cognitive deficits and neuronal degeneration mirroring AD pathology.
- Zebrafish models demonstrate conserved neural pathways implicated in AD pathogenesis.
- These models facilitate the identification of agents that replicate AD in the brain.
Conclusions:
- Zebrafish present a powerful, efficient model for investigating Alzheimer's disease mechanisms.
- This model system holds significant potential for advancing AD research and therapeutic development.
- Further research using zebrafish can accelerate the discovery of novel AD treatments.
