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Malignancy Associated Type B Lactic Acidosis: A Rare, yet Fascinating Oncological Emergency
Yashvin Onkarappa Mangala1, Nancy J Freeman2
1Clinical Fellow, Division of Hematology/Medical Oncology, Roger Williams Medical Center, an affiliate of Boston University School of Medicine, Providence, RI 02908.
Rhode Island Medical Journal (2013)
|January 29, 2024
Summary
Malignancy-associated Type B lactic acidosis is rare in solid tumors, often linked to neuroendocrine lung cancer. Early consideration of this condition, distinct from sepsis, is crucial for timely cancer treatment.
Area of Science:
- Oncology
- Metabolic Disorders
- Pathophysiology
Background:
- Type B lactic acidosis is infrequently observed in hematologic malignancies and rarely in solid tumors.
- Only 58 cases of solid tumor-associated Type B lactic acidosis have been documented since 1978.
- Lung cancer, particularly neuroendocrine subtypes, is the most common associated malignancy, often with poor differentiation and a dismal prognosis.
