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Related Experiment Video

Updated: Jul 4, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

Aspergillus and the Lung.

Iris Janssens^1,2,3, Bart N Lambrecht^1,2,3,4, Eva Van Braeckel^1,2

¹Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Seminars in Respiratory and Critical Care Medicine

|January 29, 2024

Summary

Pulmonary aspergillosis, caused by Aspergillus, presents diverse lung diseases. This review categorizes clinical entities by pathophysiology and summarizes key diagnostic findings.

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Last Updated: Jul 4, 2025

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Published on: March 22, 2012

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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Area of Science:

Medical Mycology
Pulmonology
Immunology

Background:

Aspergillus, a filamentous fungus, causes significant lung diseases, with Aspergillus fumigatus being particularly pathogenic and allergenic.
The clinical presentation of pulmonary aspergillosis is highly variable and depends on the complex interplay between the host's immune system and the fungus.
Understanding these host-pathogen interactions is crucial for diagnosing and managing the spectrum of aspergillosis-related lung conditions.

Approach:

This review provides a comprehensive overview of pulmonary aspergillosis.
Clinical entities are systematically categorized based on their primary pathophysiological mechanisms.
Key diagnostic findings across clinical, radiological, biochemical, microbiological, and histopathological domains are summarized.

Key Points:

Pulmonary aspergillosis encompasses a range of diseases driven by Aspergillus species.
Pathophysiological mechanisms dictate the diverse clinical manifestations.
Diagnostic evaluation requires integrating findings from multiple modalities.

Conclusions:

A clear understanding of the pathophysiological basis of pulmonary aspergillosis aids in clinical differentiation.
Comprehensive diagnostic summaries support accurate identification and management of lung infections caused by Aspergillus.
Further research into host-pathogen interactions can refine therapeutic strategies for aspergillosis.