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Updated: Jul 4, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

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Aspergillus and the Lung

Iris Janssens1,2,3, Bart N Lambrecht1,2,3,4, Eva Van Braeckel1,2

  • 1Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Seminars in Respiratory and Critical Care Medicine
|January 29, 2024
PubMed

Insights

Pulmonary aspergillosis, caused by Aspergillus, presents diverse lung diseases. This review categorizes clinical entities by pathophysiology and summarizes key diagnostic findings.

Area of Science:

  • Medical Mycology
  • Pulmonology
  • Immunology

Background:

  • Aspergillus, a filamentous fungus, causes significant lung diseases, with Aspergillus fumigatus being particularly pathogenic and allergenic.
  • The clinical presentation of pulmonary aspergillosis is highly variable and depends on the complex interplay between the host's immune system and the fungus.
  • Understanding these host-pathogen interactions is crucial for diagnosing and managing the spectrum of aspergillosis-related lung conditions.

Approach:

  • This review provides a comprehensive overview of pulmonary aspergillosis.
  • Clinical entities are systematically categorized based on their primary pathophysiological mechanisms.
  • Key diagnostic findings across clinical, radiological, biochemical, microbiological, and histopathological domains are summarized.

Key Points:

  • Pulmonary aspergillosis encompasses a range of diseases driven by Aspergillus species.
  • Pathophysiological mechanisms dictate the diverse clinical manifestations.
  • Diagnostic evaluation requires integrating findings from multiple modalities.

Conclusions:

  • A clear understanding of the pathophysiological basis of pulmonary aspergillosis aids in clinical differentiation.
  • Comprehensive diagnostic summaries support accurate identification and management of lung infections caused by Aspergillus.
  • Further research into host-pathogen interactions can refine therapeutic strategies for aspergillosis.

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