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Hypoxia-responsive AIEgens for precise disease theranostics.

Dongfang Liu^1,2, Mengyun Liang³, Aohua Fan^1,2

¹Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, China.

Luminescence : the Journal of Biological and Chemical Luminescence

|January 29, 2024

Summary

This summary is machine-generated.

Hypoxia-responsive aggregation-induced emission luminogens (AIEgens) offer precise disease diagnosis and treatment. These probes detect low-oxygen conditions, enhancing precision medicine for conditions like cancer and ischemia.

Keywords:

aggregation-induced emission hypoxia near-infrared photodynamic therapy theranostics

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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

Area of Science:

Biomedical Engineering
Materials Science
Medical Imaging

Background:

Hypoxia, a low-oxygen state, is a key factor in diseases like cancer and ischemia.
Aggregation-induced emission luminogens (AIEgens) are advanced materials with unique optical properties.
Biomarker-activatable probes are crucial for precision medicine and theranostics.

Purpose of the Study:

To review recent advancements in hypoxia-responsive AIEgens for biomedical applications.
To highlight the role of AIEgens in sensing and responding to hypoxic microenvironments.
To discuss the potential of these probes in disease diagnosis and therapy.

Main Methods:

Review of literature on hypoxia-responsive AIEgens and their structures (e.g., azobenzene, nitrobenzene, N-oxide).
Analysis of how AIEgen structures respond to hypoxic reduction, altering spectral and fluorescence properties.
Examination of bioapplications in imaging and therapy for tumors and ischemic diseases.

Main Results:

Hypoxia-responsive AIEgens exhibit significant spectral and fluorescence changes due to reduction-triggered structural alterations.
These probes demonstrate efficacy in imaging and therapeutic applications for cancer and ischemia.
Specific structural motifs like azobenzene, nitrobenzene, and N-oxide are effective in hypoxia sensing.

Conclusions:

Hypoxia-responsive AIEgens represent a significant advancement in theranostics and precision medicine.
These probes offer enhanced precision for diagnosing and treating hypoxia-related diseases.
Further development holds promise for improved patient outcomes in oncology and ischemia treatment.