Unfolding of Eco-Innovative Multifunctional Switch-Off Fluorescent Sensor for Omeprazole Sensing in Formulations and
Walaa Nabil Abd-AlGhafar1, Soad S Abd El-Hay2, Michael Gamal Fawzy3
1Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
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Investigations were applied for constructing carbon quantum dots (CDs) from a new natural source by environmentally benign techniques. Red grapes, rich in bioactive compounds, were utilized for the synthesis of S,N-based CDs. Microwave-assisted synthesis of CDs was applied with minimal radiation for just 6 min, which aligns with sustainability. Unlike traditional techniques that require harsh nongreen conditions, e.g., high temperature or charged molecules, this approach requires the standard household microwave temperature, which offers a readily available synthesis process with an excellent greenness level. The fabricated CDs exhibit powerful fluorescence (λex/λem of 350/445 nm) with superb water solubility. Stability and selectivity of CDs were confirmed in the presence of different ions. Crucially, the CDs were exploited for quantification of the anti-GERD drug omeprazole (OPZ) for the first time by fluorescence quenching via static quenching. The method demonstrated an excellent regression coefficient (0.9999) and a detection limit of 0.335 μg/mL. This enabled successful OPZ estimation in dosage forms, river, and tap water with %recoveries of 99.72%-101.02%. Consequently, this sensor would be a promising avenue for quality control and environmental monitoring of micropollutants. The exceptional greenness degree was confirmed using different greenness evaluation systems: Complex-GAPI, BAGI, AGREE, and nanomaterials assessment tool.
