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ACE2 Regulates Glycolipid Metabolism in Multiple Tissues
1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430000 Wuhan, Hubei, China.
Frontiers in Bioscience (Landmark Edition)
|January 30, 2024
Summary
Angiotensin-converting enzyme 2 (ACE2) regulates glucose and lipid metabolism, counteracting negative effects of the renin-angiotensin system. This review highlights ACE2's role in Type 2 diabetes and potential therapeutic applications.
Area of Science:
- Biochemistry
- Endocrinology
- Metabolic Research
Background:
- The renin-angiotensin system (RAS) traditionally regulates blood pressure.
- ACE2 modulates the RAS, forming the ACE2/A1-7/Mas axis, a counter-regulatory pathway.
- ACE2 is crucial for homeostasis and implicated in metabolic diseases like Type 2 diabetes.
Purpose of the Study:
- To review the regulation of glucose and lipid metabolism by ACE2 across various organs.
- To focus on ACE2's role in Type 2 diabetes (T2DM) and its complications.
- To offer insights into ACE2 as a therapeutic target for metabolic diseases.
Main Methods:
- Literature review of current research on ACE2.
- Analysis of ACE2's function in glucose and lipid metabolism.
- Focus on studies related to T2DM and associated conditions.
Main Results:
- ACE2 counteracts vasoconstriction, inflammation, and oxidative stress.
- ACE2 plays a significant role in glucose and lipid metabolism regulation.
- ACE2 is linked to T2DM, obesity, dyslipidemia, and diabetic nephropathy.
Conclusions:
- The ACE2/A1-7/Mas axis acts as a negative regulator of the RAS.
- ACE2 is a key player in metabolic homeostasis and disease.
- Targeting ACE2 may offer novel therapeutic strategies for T2DM and metabolic disorders.
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