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Nucleic Acid Delivery Nanotechnologies for In Vivo Cell Programming
Hannia V Balcorta1, Veronica G Contreras Guerrero1, Deepali Bisht1
1Department of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.
ACS Applied Bio Materials
|January 30, 2024
Summary
Nucleic acid therapeutics delivered via nanobiomaterials can program cells to restore function or gain new abilities for treating diseases like blindness and Alzheimer's. This review explores advancements and delivery challenges for clinical translation.
Area of Science:
- Biomaterials Science
- Molecular Medicine
- Cellular Therapeutics
Background:
- Cellular damage from disease, injury, or aging necessitates therapeutic strategies to restore or enhance cell function.
- Current limitations in treating degenerative diseases and enhancing immune responses highlight the need for advanced therapeutic modalities.
- Nucleic acids offer a versatile platform for programming cellular functions, including restoring lost functions and introducing novel therapeutic capabilities.
Purpose of the Study:
- To review the latest advancements in nanobiomaterials-based nucleic acid therapeutics for cellular programming.
- To discuss biomaterial design and delivery strategies for effective nucleic acid therapeutics.
- To identify and address barriers to the clinical translation of these novel therapies.
Main Methods:
- Review of recent scientific literature on nanobiomaterials and nucleic acid therapeutics.
- Analysis of biomaterial design principles for nucleic acid delivery.
- Examination of delivery challenges and strategies for clinical application.
Main Results:
- Nanobiomaterials are emerging as key delivery vehicles for nucleic acid therapeutics.
- Advancements in biomaterial design facilitate targeted delivery and enhanced cellular programming.
- Overcoming delivery barriers is crucial for successful clinical translation.
Conclusions:
- Nucleic acid therapeutics hold significant promise for cellular programming in medicine.
- Nanobiomaterial design and delivery are critical for realizing the therapeutic potential of nucleic acids.
- Further research and development are needed to overcome clinical translation barriers and benefit patients.
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